ChemInform Abstract: Reaction of Tetrahydro‐β‐carboline‐1‐carboxylic Acid with Isocyanates and Isothiocyanates. Synthesis of 1‐Alkyl‐ or Arylcarbamoyl‐β‐carbolines.

Abstract

Reaction of Tetrahydro-β-carboline-1-carboxylic Acid with Isocyanates and Isothiocyanates. Synthesis of 1-Alkyl-or Arylcarbamoylβ-carbolines.-The carboxylic acid (I) mentioned in the title reacts with isocyanates (II) to give the tetrahydro-β-carbolinehydantoin ring systems ( III) which are oxidized by selenium dioxide to yield the 1-substituted β-carbolines (IV). However, the reaction of (I) with the isothiocyanates (V) leads to the formation of the 2-thiocarbamoyl derivatives (VI). -(LOPEZ-RODRIGUEZ, M. L.; MORCILLO, J.; GIL, P. J.; ROSADO, L.; VENTURA, P.; Heterocycles 37 (1994) 2, 1053-1068; Dep. Quim. Org. I, Fac. Cienc. Quim., Univ.