ChemInform Abstract: REACTION OF ION‐RADICAL PERFLUOROALKYLATION. VI. TRIFLUOROMETHYLATION OF 2‐MERCAPTOPYRIMIDINES

Abstract

Bestrahlungen der Mercaptopyrimidine (I) in Gegenwart eines Überschusses von Trifluoriodmethan in flüssigem NH3 mit Hg‐Licht liefern die Trifluormethylmercapto‐pyrimidine (II); analog erhält man die Bis‐[trifluormethylmercapto]‐ pyrimidine (III).

Synthetic Methods for Compounds Having CF3–S Units on Carbon by Trifluoromethylation, Trifluoromethylthiolation, Triflylation, and Related Reactions

“…78 The radical reaction of pyridine-2-thiol proceeded well even without the use of UV irradiation (eq b, Scheme 47). 221 The radical trifluoromethylation of diheteroaryl disulfides was also reported by different groups (Scheme 48). 110,222−225 Trifluoromethanesulfenylated heteroaromatic compounds, such as indoles and pyrazoles, were conveniently synthesized by this method.…”

“…The reaction of 2-mercapto-6-(trifluoromethyl)­pyrimidin-4-ol and CF 3 I in liquid ammonia under hv initiation afforded the corresponding product in moderate yield (eq a, Scheme ) . The radical reaction of pyridine-2-thiol proceeded well even without the use of UV irradiation (eq b, Scheme ) …”

Single Electron Transfer in Radical Ion and Radical-Mediated Organic, Materials and Polymer Synthesis

“…Almost at the same time as the discovery of SET-induced addition reactions of perfluoroalkyl halides, the S RN 1 reaction involving perfluoroalkyl halides was discovered . This reaction is shown in Scheme .…”