ChemInform Abstract: Reaction of 5‐Trifluoromethyl‐2′‐deoxyuridine and 1‐Methyl‐5‐trifluoromethyluracil with Methoxyamine: Model Studies for the Interaction Between Thymidylate Synthetase and 5‐Trifluoromethyl‐2′‐deoxyuridine 5′‐Phosphate.

Abstract

The reaction of the uracil derivatives (II) with methoxyamine (III) in aqueous solution is studied to gain insight into the mechanism of inhibition of thymidylate synthetase by the deoxyuridine phosphate (I).