ChemInform Abstract: Reaction of 5‐Amino‐4‐formyl‐3‐methyl(or phenyl)‐1‐phenyl‐1H‐pyrazoles with Active Methylene Compounds: Synthesis of Fused Heterocyclic Rings.

Ahluwalia, V. K.; Dahiya, A.; Garg, V. K.

doi:10.1002/chin.199740182

Cited by 13 publications

(11 citation statements)

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“…For example, Celecoxib, SC-558, and tepoxalin were reported as cyclooxygenase 2 inhibitors [4,5], and rimonabant was identified as reducing obesity for example cannabinoid-1 inverse agonists (Figure 1) [6,7]. Additionally, pyrazole derivatives display usefulness in the fields of luminophores, fluorescence applications, agricultural research, and drug discovery [8,9,10,11,12,13,14,15]. Pyrazoles fused with other privileged structures may possess some promising pharmacological and other activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Pyrazole-Thiobarbituric Acid Derivatives: Antimicrobial Activity and Docking Studies

et al. 2016

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A one-pot reaction was described that results in various pyrazole-thiobarbituric acid derivatives as new pharmacophore agents. These new heterocycles were synthesized in high yields with a broad substrate scope under mild reaction conditions in water mediated by NHEt 2 . The molecular structures of the synthesized compounds were assigned based on different spectroscopic techniques. The new compounds were evaluated for their antibacterial and antifungal activity. Compounds 4h and 4l were the most active compounds against C. albicans with MIC = 4 µg/L. Compound 4c exhibited the best activity against S. aureus and E. faecalis with MIC = 16 µg/L. However, compounds 4l and 4o were the most active against B. subtilis with MIC = 16 µg/L. Molecular docking studies for the final compounds and standard drugs were performed using the OpenEye program.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Pyrazole-Thiobarbituric Acid Derivatives: Antimicrobial Activity and Docking Studies

et al. 2016

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“…Compounds bearing pyranopyrazole system have been found to have various biological activities, for instance antimicrobial, 1 analgesic, 2 vasodilator, 3 anticancer, 4,5 antiinflammatory, 6 inhibitors of human Chk1 kinase, 7 molluscicidal, 8 antifungicidal, 9 and also as biodegradable agrochemicals, 10 Furthermore, some of these compounds are commonly in employment such as cosmetics and pigments.…”

Section: Introductionmentioning

confidence: 99%

One-pot, four-component synthesis of pyrano[2,3-c]pyrazoles catalyzed by sodium benzoate in aqueous medium

Kiyani¹,

Samimi²,

Ghorbani³

et al. 2013

10.5267/j.ccl

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An efficient, green, and facile four-component reaction for the preparation of pyrano [2,3-c]pyrazole derivatives through the condensation reaction of aryl aldehydes, ethyl acetoacetate, malononitrile, and hydrazine hydrate or phenyl hydrazine in the presence of commercially available organocatalyst sodium benzoate under aqueous condition is reported. The products are produced with high yields and in shorter reaction times. It also is mild, safe, green and environmental friendly.

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“…Functionalized pyrano [2,3-c]pyrazoles are the most explored and widely studied and displayed significant roles in pharmaceutical fields. It possesses many interesting biological activities varying from antimicrobial [1], analgesic [2], vasodilator [3], anticancer [4], anti-inflammatory [5], inhibitors of human Chkl kinase [6], antifungicidal [7] and also as biodegradable agrochemicals [8].…”

Section: ■ Introductionmentioning

confidence: 99%

New Access to Pyrano[2,3-<i>c</i>]pyrazole-3-carboxylates via Domino Four-Component Reaction and Their Antimicrobial Activity

et al. 2019

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A library of some novel classes of pyrano[2,3-c]pyrazole-3-carboxylates was synthesized by employing uncatalyzed domino four-component reaction using diethyloxaloacetate, hydrazine hydrate, aldehydes and malononitrile in refluxing of ethanol-acetic acid solvent systems. Series of domino reactions involving of pyrazolone formation, Michael addition, and Thorpe-Ziegler cyclization reaction managed to produce the cyclized products from moderate to excellent yield. This protocol provides a reliable, general and salient procedure for the title compound using a one-pot approach. Preliminary biological screening unveiled limited potentials of this class of compounds for antimicrobial lead compound due to its limited solubility properties.

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ChemInform Abstract: Reaction of 5‐Amino‐4‐formyl‐3‐methyl(or phenyl)‐1‐phenyl‐1H‐pyrazoles with Active Methylene Compounds: Synthesis of Fused Heterocyclic Rings.

Cited by 13 publications

References 0 publications

Synthesis of Pyrazole-Thiobarbituric Acid Derivatives: Antimicrobial Activity and Docking Studies

Synthesis of Pyrazole-Thiobarbituric Acid Derivatives: Antimicrobial Activity and Docking Studies

One-pot, four-component synthesis of pyrano[2,3-c]pyrazoles catalyzed by sodium benzoate in aqueous medium

New Access to Pyrano[2,3-<i>c</i>]pyrazole-3-carboxylates via Domino Four-Component Reaction and Their Antimicrobial Activity

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