ChemInform Abstract: Rapid Entry to Highly Substituted 4,5‐Dihydronicotinonitriles.

Abstract

Rapid Entry to Highly Substituted 4,5-Dihydronicotinonitriles.-The one-pot preparation of the title compounds such as (III), (V), and (IX) by simple condensation of salicylaldehyde with malononitrile and aromatic heterocyclic ketones or by condensation of 2-imino-3-cyanocoumarins (I) with active methylene compounds in the presence of ammonium acetate is described. -(EL-AHL, A. A. S.; AFEEFY, H.; METWALLY, M. A.; Rev.

Sodium stearate-catalyzed multicomponent reactions for efficient synthesis of spirooxindoles in aqueous micellar media

“…Further studies showed that increasing the amount of sodium stearate could improve the reaction significantly. Inspired by the result, we have changed the catalyst amount from 1 to 12 mol %, finding that 10 mol % of sodium stearate was good enough (Table 1, entries [14][15][16][17].…”

Action of Hydrazines on 2‐(2‐Oxindolin‐3‐ylidene)malononitrile, (E,Z)‐Ethyl 2‐cyano‐2‐(2‐oxindolin‐3‐ylidene)acetate and Isatin‐β‐thiosemicarbazone as a Source of Spiro Indoline‐pyrazole Systems

“…Isatin and a number of its derivatives posses a reactive carbonyl group that readily undergoes condensation reactions under mild conditions . It was therefore suitable as a precursor for the synthesis of heterocycles incorporating spiro indolines for pharmacological evaluation , medicinal application as muscle relaxants, and anti‐inflammatory agents .…”

Dicyanomethylene compounds and heterocyclization of substituted carbohydrazides

“…Additionally, the reaction of 2 with arylazoaminopyrazoles [12, 13], 2‐mercaptobenzazoles [14], thiocarbohydrazide, and thiocarbazones [15] as well as N ‐arylisoindolines [16] have been reported. Closely analogous 3‐(dicyano‐methylene)‐2‐indolone ( 3 ) [17] which is a ylidene malononitrile like 2 reacted with thiobarbituric acid [18], S,S ‐ and N,S ‐acetals [19], cyclohexanedione [20], and another active methylene systems to give spirohetero‐cyclic compounds [21, 22]. The reaction of N,N ′‐diarylacetamidines with 2 afforded indenoazepine‐6‐ones [23].…”