ChemInform Abstract: Pyrrolidine‐2,3,4‐tricarboxylic Anhydrides. Part 1. Organocatalytic Synthesis and Fusion of Pyrrole Ring by the Action of p‐Fluorobenzylamine.
Abstract:Octahydropyrrolo[3,pyrroles (V) are synthesized by 1,3-dipolar addition of maleic anhydride (II) to benzylidene amino acid esters (I) followed by opening of the anhydride fragment and recyclization. Compounds (V) inhibit enzymatic activity of thrombin. -(KUDRYAVTSEV*, K. V.; TROFIMOVA, E. V.; BORISOVA, A. O.; Russ. J. Org. Chem. 47 (2011) 4, 556-562, http://dx.doi.org/10.1134/s1070428011040142 ; Fac. Chem., Moscow State Univ., Moscow 119992, Russia; Eng.) -R. Langenstrassen 41-106
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