ChemInform Abstract: Preparation of the C1—C10 Fragment of Carbonolide B. A Relay Approach to Carbomycin B.

Abstract

Preparation of the C1-C10 Fragment of Carbonolide B. A Relay Approach to Carbomycin B. -The allofuranoside (I) reacts with magnesium compound (II) to give selectively the furanoside (III). It is elaborated to the C1-C10 fragment (IX) via hydroboration of the prochiral double bond of (III), oxidation cleavage between C5-C6 of the diol (V) and subsequent three-carbon elongation at the C5-position. -(SHIMURA, T.; KOMATSU, C.; MATSUMURA, M.; SHIMADA, Y.; OHTA, K.; MITSUNOBU, O.; Tetrahedron Lett. 38 (1997) 48, 8341-8344; Dep. Chem., Coll. Sci. Eng., Aoyama Gakuin Univ., Setagaya, Tokyo 157, Japan; EN)