ChemInform Abstract: Practical Routes to 2,6‐Disubstituted Pyridine Derivatives.

Abstract

Pyridine derivatives R 0380Practical Routes to 2,6-Disubstituted Pyridine Derivatives. -The regioselective functionalization of the pyridine core becomes possible with the BuLi-DMAE superbase for selective α-lithiation followed by a Grignard reaction. The route is applied to prepare pyridines bearing an aryl group in the 6-position and an alkyl group in the 2-position. The pyridines are studied for their self-assembly abilities at the interface between an organic solution and the basal plane of graphite. -(VANDROMME, L.; REISSIG*, H.-U.; GROEPER, S.; RABE, J. P.; Eur.