ChemInform Abstract: Practical Demethylation of Podophyllotoxin and Efficient Preparation of 4‐Amino‐4‐deoxy‐4′‐demethylepipodophyllotoxin.

Abstract

The regioselective demethylation of podophyllotoxin (I) is smoothly achieved using methionine and methylsulfonic acid in TFA or in acetone/water.

An intrinsically fluorescent glycoligand for direct imaging of ligand trafficking in artificial and living cell systems

“…It is possible to append a fluorescent moiety to the molecule to be tracked. This approach has been successfully applied by conjugating a variety of fluorescent probes including synthetic organic fluorophores (e.g., fluorescein, 14 NBD, 15,16 rhodamine 15 ), inorganic nanoparticles (e.g., quantum dots 17 ) and fluorescent proteins. 18 However, such a conjugation may induce a modification of the physico-chemical properties, such as polarity, acidity, metal affinity or hydrophobicity.…”