ChemInform Abstract: Practical Asymmetric Approach to Pyrrolidinones: Efficient Synthesis of (+)‐Preussin and (‐)‐AHPPA.

Abstract

Practical Asymmetric Approach to Pyrrolidinones: Efficient Synthesis of (+)-Preussin and (-)-AHPPA. -The key steps in the synthesis of the title compounds (VI) and (VII) are stereoselective cycloaddition of the ketene (III) to the enol ether (II) and efficient Beckmann ring expansion to the pyrrolidinone (V). -(KANAZAWA, A.; GILLET, S.; DELAIR, P.; GREENE, A. E.; J.