ChemInform Abstract: POTENTIAL VIRUSTATICS. PART 1‐ QUINOXALINES

Abstract

Die Chinoxaline (II) und (III), die gegen DNS‐ und RNS‐Viren wirksam sind, werden aus den Diaminen (I) über die entsprech‐ enden Chinoxalinone durch Reaktion mit Phosphoroxychlorid erhalten.

Synthesis of Some New Quinoxalines and 1,2,4‐Triazolo[4,3‐a]‐quinoxalines for Evaluation of in vitro Antitumor and Antimicrobial Activities

“…Compound 5 was prepared as previously described [7]. Reacting 5 with ethyl cyclohexanone-2-carboxylate by adapting the reaction conditions reported for the preparation of analogous compounds [8] yielded 2-(3-oxo-3,3a,4,5,6,7-hexahydroindazol-2-yl)-3-phenylquinoxaline.…”

Synthesis and Antimicrobial Activity ofSome New Thioether Derivatives of Quinoxaline

“…Compounds containing the quinoxaline nucleus exhibit a broad spectrum of biological activity such as antibacterial [1][2][3] , antifungal 4,5 , antiviral 6 , anticancer 7 , antituberculosis 8 , antimalarial 9 and anti-inflammatory 10 . Thioethers have also been reported for their bactericidal, fungicidal, anti-inflammatory anticholestemic, hypolipidemic and neurotropic activities 11,12 , therefore in continuation of our previous work 13 on 2-chloro-3methylquinoxaline therefore it was thought worthwhile to synthesize thioether derivatives of quinoxaline in search of better antimicrobial agents.…”

Design, synthesis, anticancer evaluation and molecular docking of new V600EBRAF inhibitors derived from pyridopyrazinone

“…1 H NMR spectra showed additional aromatic protons at δ 6.76-8.10 ppm in addition to signal at δ 8.10-8.19 ppm corresponding to benzylidene proton for compounds 5a-d. Adopting cyclization with the aid of bromine and sodium acetate in glacial acetic acid at room temperature [31,32] for compounds 5a-d afforded compounds 6a-d. 1 H NMR spectra showed additional singlet signal at δ 5.82-6.21 ppm corresponding triazine proton.…”