ChemInform Abstract: Pimarane Diterpenes from the Endophytic Fungus Eutypella sp. BCC 13199.

Isaka, Masahiko; Palasarn, Somporn; Prathumpai, Wai; Laksanacharoen, Pattiyaa

doi:10.1002/chin.201208206

Cited by 8 publications

(16 citation statements)

References 1 publication

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“…Eutypellin A is a γ-lactone that exhibited cytotoxic activity against NCI-H187, MCF-7, KB, and nonmalignant Vero cells with IC 50 values of 12, 84, 38, and 88 µM, respectively. Ellipticine, a positive control, exhibited cytotoxic activity against NCI-H187, KB, and nonmalignant Vero cells with IC 50 values of 3.6, 2.5, and 5.5 µM, respectively (Isaka et al 2009a). …”

Section: Compounds From Endophytic Fungi Of Terrestrial Plantsmentioning

confidence: 98%

“…Diaporthein B exhibited significant cytotoxic activities against NCI-H187, MCF-7, KB, and Vero cell lines with an IC 50 of 0.15, 1.2, 3.2, and 2.8 µM, respectively. Scopararane A exhibited significant cytotoxic activities against NCI-H187, MCF-7, KB, and Vero cell lines with an IC 50 value of 0.024, 5.7, 9.3, and 2.6 µM, respectively (Isaka et al 2011).…”

Section: Compounds From Endophytic Fungi Of Terrestrial Plantsmentioning

confidence: 99%

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Fungal Endophytes: An Amazing and Hidden Source of Cytotoxic Compounds

Deshmukh

Verekar

2014

Microbial Diversity and Biotechnology in Food Security

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This review covers substantially the cytotoxic compounds isolated from endophytic fungi from terrestrial and mangrove plants during [2009][2010][2011][2012]. Endophytes living asymptomatically within plant tissues have been found in almost all plants studied to date. Many of the compounds reported here were originally isolated from plants, then from endophytic fungi, whereas some are exclusively isolated from endophytic fungi. The anticancer activities in this review are from the published cytotoxicity against specific cancer cell lines. Development of these natural compounds is based on their cytotoxic activity profiles, chemical structures, and potential structure-activity relationship deduced from the biochemical and cytotoxic studies.

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Section: Compounds From Endophytic Fungi Of Terrestrial Plantsmentioning

confidence: 98%

Section: Compounds From Endophytic Fungi Of Terrestrial Plantsmentioning

confidence: 99%

Fungal Endophytes: An Amazing and Hidden Source of Cytotoxic Compounds

Deshmukh

Verekar

2014

Microbial Diversity and Biotechnology in Food Security

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“…All six γ-lactones exhibited cytotoxicity against breast cancer cell line MDA-MB-231 with inhibitory rates of 24.4, 24.2, 23.1, 24.4, and 24.6 %, respectively, at a concentration of 10 μg/mL. Eutypellin A is a γ-lactone that exhibited cytotoxic activity against NCI-H187 (human small-cell lung cancer cells), MCF-7, KB, and nonmalignant Vero cells with IC 50 values of 12, 84, 38, and 88 μM compared to the standard ellipticine, which exhibited IC 50 values of 3.6, 2.5, and 5.5 μM, respectively (Isaka et al 2009 ). Eutypellin A was isolated from the endophytic fungus Eutypella sp.…”

Section: Lactonesmentioning

confidence: 98%

“…A new eudesmane sesquiterpene, ent-4(15)-eudesmen-11-ol-1-one, was isolated from the endophytic fungus Eutypella sp. BCC 13199 associated with Etlingera littoralis (Earth ginger) (Isaka et al 2009 ). It showed weak cytotoxic activity against human cancer cells NCI-H187, MCF-7, KB, and Vero, with IC 50 values of 11, 20, 32, and 32 μM, respectively (Isaka et al 2009 ).…”

Section: Terpenesmentioning

confidence: 99%

“…BCC 13199 associated with Etlingera littoralis (Earth ginger) (Isaka et al 2009 ). It showed weak cytotoxic activity against human cancer cells NCI-H187, MCF-7, KB, and Vero, with IC 50 values of 11, 20, 32, and 32 μM, respectively (Isaka et al 2009 ). Merulin A (nor-chamigrane endoperoxide) and merulin C (chamigrane endoperoxide) are two new sesquiterpenes produced by the endophytic fungus XG8D, a basidiomycete isolated from the mangrove plant Xylocarpus granatum (Meliaceae).…”

Section: Terpenesmentioning

confidence: 99%

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Endophytic Fungi: Novel Sources of Anticancer Molecules

Kumar

Rai

Gaur

et al. 2013

Advances in Endophytic Research

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Cancer is an enormous global health burden, touching every region of the world. The term "anticancer" is based on the assessment of the authors of the paper of the cytotoxicity of each compound against specifi c cancer cell lines. Endophytic fungi, fungi that are residing asymptomatically in internal tissues of all higher plants, are of growing interest as promising sources of biologically active agents. Endophytic fungi are one of the most creative groups of secondary metabolite producers that play important biological roles for human life. This chapter mainly focuses on endophytic fungi, which produce anticancer bioactive compounds such as paclitaxel, podophyllotoxin, camptothecin, vinblastine, hypericin, and diosgenin. The uniqueness of the endophytic community of fungi is stressed as a promising source of novel compounds with anticancer activity. Endophytes represent a dependable source of specifi c secondary metabolites and can be manipulated both physicochemically and genetically to increase yields of desired metabolites and to produce novel analogues of active metabolites.

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Bioactive Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D‐1

Wang

Sun

Wang

2018

Chemistry & Biodiversity

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Two new pimarane diterpenes, libertellenone M (1) and libertellenone N (2), together with five known compounds were isolated from the culture extract of Eutypella sp. D-1 derived from high-latitude soil of the Arctic. The structures of these compounds were determined by spectroscopic data as well as experimental and calculated electronic circular dichroism (ECD) analysis. Antimicrobial and cytotoxic activities of the isolated compounds were evaluated. Compound 3 exhibited weak antibacterial activity against Escherichia coli, Bacillus subtilis, and Vibrio vulnificus, each with MIC values of 16 μg/mL. Compounds 2 and 3 showed moderate cytotoxic activity against K562 and MCF-7 cell lines with IC values of 7.67 and 9.57 μm, respectively.

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ChemInform Abstract: Pimarane Diterpenes from the Endophytic Fungus Eutypella sp. BCC 13199.

Cited by 8 publications

References 1 publication

Fungal Endophytes: An Amazing and Hidden Source of Cytotoxic Compounds

Fungal Endophytes: An Amazing and Hidden Source of Cytotoxic Compounds

Endophytic Fungi: Novel Sources of Anticancer Molecules

Bioactive Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D‐1

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