ChemInform Abstract: Phytochemicals from Genus Swertia and Their Biological Activities

Pant, Neeraj; Jain, D. C.; Bhakuni, R. S.

doi:10.1002/chin.200103247

Cited by 21 publications

(26 citation statements)

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“…3,4 However, populations of S. chirata are diminishing and the plant has been considered as critically endangered. 1,5 Other species like S. decussata Schult. and S. bimaculata (Siebold and Zuccarini.)…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, anti-acetylcholinesterase and anti-glycosidase properties of three species of Swertia, their xanthones and amarogentin: A comparative study

Nag

Das²,

Das³

et al. 2015

Phcog J

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Aim:The aim of the study was to analyze the antioxidant, anti-amylase, anti-glucosidase and antiacetylcholinesterase (anti-AChE) properties of the leafy shoots of three Indian species of Swertia e.g. Swertia chirata and its substitutes Swertia bimaculata, and Swertia decussata, their xanthones and amarogentin. Methods: Antioxidant activity of the methanolic extracts of leafy shoots was measured in terms of DPPH, superoxide and nitric oxide radical scavenging activities as well as metal chelating properties. Enzyme inhibitory properties were measured using AChE, α-amylase and α-glucosidase respectively. Five xanthones bellidifolin (1), swerchirin (2), decussatin (3), mangiferin (4) and 1-hydroxy-3,5,8-trimethoxy xanthone (6) and one iridoid, amarogentin (5) were isolated from Swertia chirata. The activities of the isolated components were compared. Results: Swertia chirata exhibited best antioxidant and antiAChE properties than the other two species. The plants also possessed α-glucosidase inhibitory properties but weak α-amylase inhibitory activity. Highest activities were observed in Swertia chirata. We report here, for the first time, the antioxidant, anti-AChE and anti-glycosidase activity of 1-hydroxy-3,5,8-trimethoxy xanthone. This xanthone had strongest DPPH radical scavenging activity and anti-AChE property. Conclusion: The results suggest the beneficial effects of the xanthones of Swertia chirata. But further study should be carried out to prove the efficacy in vivo.

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Section: Introductionmentioning

confidence: 99%

Antioxidant, anti-acetylcholinesterase and anti-glycosidase properties of three species of Swertia, their xanthones and amarogentin: A comparative study

Nag

Das²,

Das³

et al. 2015

Phcog J

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“…Extracts of S. chirayita have been shown to possess antioxidative, antihepatotoxic and hypoglycemic, anti-inflammatory, antimalarial, anticarcinogenic, and antimicrobial activities (Kar et al 2003;Saha et al 2004;Tripathi et al 2005). Previous reports documented the presence of flavonoids, xanthones, terpenoids, iridoid and secoiridoid glycoside, that are responsible for therapeutic properties in S. chirayita (Pant et al 2000). The bioactive constituents include the xanthone and secoiridoid glycosides consisting of mangiferin, amarogentin and swertiamarin.…”

Section: Introductionmentioning

confidence: 99%

LC-ESI/MS determination of xanthone and secoiridoid glycosides from in vitro regenerated and in vivo Swertia chirayita

Kumar

Chandra²

2014

Physiol Mol Biol Plants

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A rapid analytical method has been developed to determine xanthone and secoiridoid glycoside in in vitro and in vivo Swertia chirayita extracts. Ultra performance liquid chromatography-electrospray ionization mass spectrometry (LC-ESI/MS) was applied and validated for the analysis of xanthone and secoiridoid glycoside a potential active component isolated from methanolic extracts of in vitro and in vivo Swertia chirayita plantlets. Chromatographic separation was achieved on a RP-C18 column using gradient elution. Mangiferin (Xanthone), Amarogentin and Swertiamarin (Secoiridoid glycosides) were identified in both the extracts. In the LC/ESI-MS spectra, major [M+H] + and [M+Na] + ions were observed in positive ion mode and provided molecular mass information. An ultra-performance liquid-chromatography in combination with electrospray ionization tandem mass spectrometry involving metal cationisation was successfully utilized for the rapid identification of xanthone and secoiridoid glycosides. This method is suitable for the routine analysis, as well as for the separation and identification of known and novel secoiridoid glycoside and xanthone.

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“…Traditional uses, demand from pharamaceutical industries and research activities adversely affect the natural population of this valuable medicinal herb. Previous reports documented the presence of flavonoids, xanthones, terpenoids, iridoid and secoiridoid glycosides, that are responsible for therapeutic properties in S. chirayita [14]. Mangiferin has been reported to possess various biological activities like antitumour, antiviral, antioxidant, antidiabetic and immunomodulatory activity [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

In vitro organogenesis secondary metabolite production and heavy metal analysis in Swertia chirayita

et al. 2014

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An efficient protocol of plant regeneration through direct and indirect organogenesis in Swertia chirayita was developed. Explants cultured on Murashige and Skoog medium supplemented with 2,4-D (0.5 mg L−1) with combination of Kinetin (0.5 mg L−1) showed the highest frequency (84%) of callusing and 1.0mg L−1 6-benzyladenine (BA) in combination with (100 mg L−1) Adenine sulphate (Ads) + (0.1 mg L−1) Indole acetic acid (IAA) was excellent for maximum adventitious shoot (12.69 ± 1.30) formation in four week of culture. A maximum number of (7.14 ± 0.99) shoots were developed per leaf explants through direct organogenesis. The highest frequency of rooting (11.46 ± 1.56) was observed on MS medium augmented with IAA (1.0 mg L−1). Well-rooted shoots transferred to plastic pots containing a soilrite: sand mix and then moved to the greenhouse for further growth and development. Four major secondary metabolites were analyzed and quantified using high performance liquid chromatography. Amount of secondary metabolites was found significantly higher, in in vitro plantlets compared to in vivo plantlets and callus raised from S. chirayita. Higher heavy metal accumulation in in vitro as compared to in vivo plantlets correlates higher secondary metabolite production supporting that they play regulatory role in influencing the plant secondary metabolism.

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ChemInform Abstract: Phytochemicals from Genus Swertia and Their Biological Activities

Cited by 21 publications

References 0 publications

Antioxidant, anti-acetylcholinesterase and anti-glycosidase properties of three species of Swertia, their xanthones and amarogentin: A comparative study

Antioxidant, anti-acetylcholinesterase and anti-glycosidase properties of three species of Swertia, their xanthones and amarogentin: A comparative study

LC-ESI/MS determination of xanthone and secoiridoid glycosides from in vitro regenerated and in vivo Swertia chirayita

In vitro organogenesis secondary metabolite production and heavy metal analysis in Swertia chirayita

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