“…In fact, the nucleophilic substitutions of phosphoramidites have rarely been detected to depend on the nucleophile concentration. 24 Kinetic studies on alcoholysis have been performed in pseudo-first order conditions 16 and the transaminolysis of phosphoramidites has been reported to be independent of the amine concentration. 25 Reaction of phosphoramidites with tetrazole 19 is dependent on tetrazole concentration because of the acidic role of the reactant.…”