ChemInform Abstract: Phosphoric Acid Catalyzed Desymmetrization of Bicyclic Bislactones Bearing an All‐Carbon Stereogenic Center: Total Syntheses of (‐)‐Rhazinilam and (‐)‐Leucomidine B.

Abstract

Desymmetrization of bislactones of type (I) with an alcohol in the presence of a chiral imidodiphosphonic acid as catalyst produces enantioenriched 4‐substituted‐4‐formylpimelate monoacids including Kuehne′s aldehyde (IIIa).