ChemInform Abstract: PEPTIDE SYNTHESIS ON THE NEW POLYOXYETHYLENE‐POLYSTYRENE GRAFT COPOLYMER, SYNTHESIS OF INSULIN B21‐30

Bayer, Ernst; Dengler, Michael A.; Hemmasi, Bahram

doi:10.1002/chin.198525357

Cited by 2 publications

(2 citation statements)

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“…polyacrylamide, polyacrylate, polystyrene with different percentages of cross-linker and polyvinyl polymer), can exhibit a higher pressure tolerance and better swelling properties in the presence of organic solvents than the polysaccharides; even if a high cross-linking content decreases the diffusion rate and therefore the immobilisation and interaction rates [136]. Furthermore, polystyrene properties have been extended by grafting polyethylene glycol (PEG) chains onto lowcross-linked polystyrene; these new solid phases were Tentagel resins [137]. Tentagel resins have good swelling characteristics in both organic and aqueous media; the ability of the resin to swell in aqueous media is an essential feature for many samples.…”

Section: Affinity Devicesmentioning

confidence: 98%

Antibody-Like Peptides as a Novel Purification Tool for Drugs Design

Tozzi¹,

Giraudi²

2006

CPD

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New pharmaceutical approaches, such as biotechnology industry, genomic and proteomic studies, require the development of new analytical and preparative tools that should allow the resolution and the characterisation of complex sets of molecule mixtures in a high-throughput mode with the isolation of a single substance from complex matrices in a high degree of purity, low costs and wide availability. In this review we discuss the design of a tailor-made peptide by focusing our attention on the bioinformatic techniques and combinatorial approaches. Then synthesis, purification and characterisation of peptides with recognition properties are discussed by considering different approaches and their fitness to drug design. Moreover, the development of affinity devices and the discussion of their characteristics to optimise the purification phase are reported. Applications of peptide ligands that bind pharmaceutical compounds (i.e. therapeutic proteins, monoclonal antibodies, hormones) are described and analytical tools mentioned and evaluated. Future perspectives, in particular alternative applications of peptide ligands and their substitution with peptidomimetic compounds, are described.

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Section: Affinity Devicesmentioning

confidence: 98%

Antibody-Like Peptides as a Novel Purification Tool for Drugs Design

Tozzi¹,

Giraudi²

2006

CPD

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“…Moreover the POE 6000 is characterised by difficult handling and the necessity of using ethyl ether to precipitate the polymer. Finally, synthesis on soluble supports is difficult to automate 47…”

Section: Supports For Solid Phase Biocatalysismentioning

confidence: 99%

Enhancement of the enzymatic digestibility of sugarcane bagasse by steam pretreatment impregnated with hydrogen peroxide

Rabelo

Rossell

Rocha

et al. 2012

Biotechnology Progress

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Sugarcane bagasse was subjected to steam pretreatment impregnated with hydrogen peroxide. Analyses were performed using 2(3) factorial designs and enzymatic hydrolysis was performed at two different solid concentrations and with washed and unwashed material to evaluate the importance of this step for obtaining high cellulose conversion. Similar cellulose conversion were obtained at different conditions of pretreatment and hydrolysis. When the cellulose was hydrolyzed using the pretreated material in the most severe conditions of the experimental design (210 °C, 15 min and 1.0% hydrogen peroxide), and using 2% (w/w) water-insoluble solids (WIS), and 15 FPU/g WIS, the cellulose conversion was 86.9%. In contrast, at a milder pretreatment condition (190 °C, 15 min and 0.2% hydrogen peroxide) and industrially more realistic conditions of hydrolysis (10% WIS and 10 FPU/g WIS), the cellulose conversion reached 82.2%. The step of washing the pretreated material was very important to obtain high concentrations of fermentable sugars.

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ChemInform Abstract: PEPTIDE SYNTHESIS ON THE NEW POLYOXYETHYLENE‐POLYSTYRENE GRAFT COPOLYMER, SYNTHESIS OF INSULIN B21‐30

Cited by 2 publications

References 1 publication

Antibody-Like Peptides as a Novel Purification Tool for Drugs Design

Antibody-Like Peptides as a Novel Purification Tool for Drugs Design

Enhancement of the enzymatic digestibility of sugarcane bagasse by steam pretreatment impregnated with hydrogen peroxide

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