ChemInform Abstract: p‐Nitrophenyl Ethylthioester in Enantioselective Organocatalytic Michael Additions: Different Behavior of β‐Aryl and β‐Alkyl Enals.

Abstract

The differences in the reactivity of the thioesters (I) with β‐alkyl and β‐aryl‐substituted enals (II) are overcome by optimization allowing the synthesis of diastereomeric mixtures of Michael adducts (III) and (IV).