Abstract:Oxyazapeptides: Synthesis, Structure Determination, and Conformation Analysis. -Substituting the typical native N-C α bond with an O-N α bond, completely new, previously unknown peptidomimetics are created, which are hydrolytically stable and display very interesting conformational behavior. Force field calculations reveal that the barrier to rotation around the O-N α bond is five times lower than that around the N-N α bond in azapeptides. It is also shown by conformational analysis that the oxyaza moiety can … Show more
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