ChemInform Abstract: Oxidative Modification of NK30424A and B Enhance Inhibitory Effect on Lipopolysaccharide‐Induced Tumor Necrosis Factor‐α Promoter Activity.

Abstract

Oxidative Modification of NK30424A and B Enhance Inhibitory Effect on Lipopolysaccharide-Induced Tumor Necrosis Factor-α Promoter Activity. -Besides the previously discovered TNF-α inhibitors NK 30424A and B four minor components with more strong activity are discovered in the culture broth of Streptomyces sp. NA 30424. The structures of these mono-oxidation products from their stereoisomeric parent compounds are elucidated as sulfoxides. However, the stereochemistry of these products is still unclear. The sulfoxides are approximately 30≈120 times more potent than their parent compounds and thus, they would be better candidates for treatment of pathophysiologic diseases.-(TAKAYASU, YOSHIYUKI; TSUCHIYA,