ChemInform Abstract: Oxadiazole: A Biologically Important Heterocycle

Abstract

Review: 39 refs.

Synthesis and Characterization Platinum (II), Palladium (II) and Nickel (II) Complexes with some Heterocyclic Ligand of 1,3,4-Oxadazole Derivative

“…Oxadiazole, heterocyclic nucleus has a wide attention of the chemist in search for the new therapeutic molecules (Somani and Shirodkar, 2009). Among them, 1,3,4-oxadiazole is considered to be derived from furan by replacement of two methane(-CH=)groups, by two pyridine type nitrogen (-N=).…”

Latest Update on Pharmacological Activities of 1,3,4-Oxadiazole Derivatives

“…Oxadiazole is considered to be derived from furan by replacement of two methane (-CH=) group by two pyridine type nitrogen (-N=). There are four possible isomers of oxadiazole (1,2,3,4) depending on the position of nitrogen atom in the ring and are numbered as shown in Figure 1.…”

“…A Wide variety of substituted 1,3,4-oxadiazoles have attracted considerable attention in the field of drug discovery because of their wide range of pharmacological activities. Oxadiazoles have occupied a specific place in the field of medicinal chemistry due to its wide range of activities [1].…”

Multistep synthesis of 1-[{(5-alkenyl/hydroxyalkenylsubstituted)-1,3,4-oxadiazol-2-yl}-methyl]-2-methyl-1H-benzimidazole series and in vitro anticancer screening, SAR studies

“…Despite this, 1,3,4-oxadiazoles were found to be the medicinate backbone in the number of therapeutic agents (Lam et al, 2010), such as fenadiazole [4] (hypnotic drug), raltegravir [5] (anti HIV drug), furamizole [6] (antibacterial agent), BB-83698 (potent PDF inhibitor), tiodazosin (antihypertensive drug), nesapidil [7] (antiarrhythemic drug), Zibotentan (Oliveira et al, 2012) (ZD4054) [8] (anticancer agent) and pleconaril [9] (antiviral drug). These 1,3,4-oxadiazoles can be synthesized from different methods such as from the reaction of substituted propanoic acid and alkyl/aryl hydrazide, which undergo cyclization to give 1,3,4-oxadiazoles in the presence of POCl 3 (Somani and Shirodkar, 2009), and several other synthetic pathways are reported for the synthesis of 1,3,4-oxadiazoles (Husain and Ajmal, 2009 Both of the rings are very important pharmacophore in modern drug discovery, because both possess a number of biological (anticonvulsant and antimicrobial) activities (Bin et al, 1998). These derivatives were also synthesized by the microwave assisted method (Jha et al, 2010, Rashid et al, 2012 from aromatic acid and trichloroacetic acid.…”