ChemInform Abstract: Organocatalytic Enantioselective Intramolecular Oxa‐Michael Reaction of Enols: Synthesis of Chiral Isochromenes.

Abstract

An enantioselective intramolecular oxa‐Michael reaction of enols catalyzed by a squaramide‐containing tertiary amine based bifunctional organocatalyst, which efficiently activates the o‐homoformyl chalcones, provides chiral isochromenes in moderate yields and good to excellent enantioselectivities.