ChemInform Abstract: Organocatalytic Asymmetric Multicomponent Reactions of Aromatic Aldehydes and Anilines with β‐Ketoesters: Facile and Atom‐Economical Access to Chiral Tetrahydropyridines.

Abstract

A chiral 1,1′‐spirobiindane‐7,7′‐diol phosphoric acid is successfully applied as catalyst for the asymmetric synthesis of tetrahydropyridines (IV) from ketoester (I), aldehydes (II), and anilines (III).