Abstract:One-Pot Synthesis of Pyrimidine-5-carboxaldehyde and Ethyl Pyrimidine-5-carboxylate by Utilizing Pyrimidin-5-yllithium.-Reaction of pyrimidin-5-yllithium, generated by metalation of 5-bromopyrimidine (I), with ethyl formate (II) or cyanoformate (IV) at low temperatures leads to the formation of 5-pyrimidinecarboxaldehyde ( III) and the pyrimidinecarboxylate (V) respectively. -(RHO, T.; ABUH, Y. F.; Synth. Commun. 24 (1994) 2, 253-256; Dep. Med. Chem., Center Drug Design Dev., Coll. Pharm., Univ., Toledo, OH … Show more
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