ChemInform Abstract: One‐Pot Microwave‐Promoted Synthesis of Nitriles from Aldehydes via tert‐Butanesulfinyl Imines.

Tanuwidjaja, Jessica; Peltier, Hillary M.; Lewis, Jared C.; Schenkel, Laurie B.; Ellman, Jonathan A.

doi:10.1002/chin.200813041

Cited by 1 publication

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“…Apart from the atom economic nature of the reaction, another important feature of the reaction is that the reaction can be carried out at relatively lower temperature under microwave irradiation. Since higher temperature can lead to formation of nitrile compound of the corresponding aldehyde in appreciable amounts 22 therefore this methodology can significantly resist the formation of such byproducts. In our case the reactions proceeded without significant formation of any byproduct.…”

Section: Resultsmentioning

confidence: 99%

An Atom Economic Acid Catalyzed Synthetic Method for Aromatic Imines

Baruah

Fisyuk

Кулаков

et al. 2017

AJCPS

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A new one-pot acid catalyzed synthetic methodology has been described for synthesis of aromatic imines. The reaction is carried out under microwave irradiation using minimum amount of methanol as solvent. Aqueous solution of the acid catalyst act as solvent for amine dissolution. The reaction yields substantial yield of product imine. The simplicity and environmentally benign nature of the process are the most notable features. The process can also be extended to include wide number of substrates. Product of the reaction can be isolated by simple procedure. The reaction can be carried out under mild conditions without heating to a higher temperature which eventually prevents the formation of nitrile byproducts in the reaction. Byproduct formation was significantly less during the reaction.

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Section: Resultsmentioning

confidence: 99%