ChemInform Abstract: One‐Pot Conversion of Carbohydrates into Pyrrole‐2‐carbaldehydes as Sustainable Platform Chemicals.

Abstract

One-Pot Conversion of Carbohydrates into Pyrrole-2-carbaldehydes as Sustainable Platform Chemicals. -Carbohydrates such as glucose (I) are converted into title compounds (III) by the reaction with primary amines (II) in the presence of oxalic acid. Further cyclization of these compounds affords fused poly-heterocyclic systems. The products of the mild Maillard reaction of carbohydrates and amino esters can be further transformed into natural pyrrole alkaloids, such as lobechine and hanishin. -(ADHIKARY, N. D.; KWON, S.; CHUNG, W.-J.; KOO*, S.; J. Org. Chem. 80 (2015) 15, 7693-7701, http://dx.doi.org/10.1021/acs.joc.5b01349 ; Dep. Energy Sci. Technol., Myongji Univ., Yongin, Gyeonggi 449-728, S. Korea; Eng.) -M. Paetzel 51-116