ChemInform Abstract: NUCLEOPHILER AUSTAUSCH DER HYDROXYL‐GRUPPE DURCH BROM IN 1‐AMINOMETHYLCYCLOHEXANOL

Abstract

Durch Reduktion von Cyclohexanon‐cyanhydrin (I) mit Lithium‐aluminiumhydrid in Äther erhält man das 1‐Aminomethyl‐cyclohexanol (II) (Ausbeute 79%), das mit 48%iger Bromwasserstoffsäure in das Hydrobromid (III) übergeführt wird.

Synthesis and Evaluation as Glycosidase Inhibitors of Carbasugar‐Derived Spirodiaziridines, Spirodiazirines, and Spiroaziridines.

“…Colourless oil. 13 (7) 50 values were determined at 378 in 0.08m KH 2 PO 4 /K 2 HPO 4 or NaH 2 PO 4 /Na 2 HPO 4 buffer, with 4-nitrophenyl b-d-glucopyranoside as the substrate ([S] % K M ). 15 3038w, 2954w, 1751s, 1594w, 1443w, 1377m, 1248s, 1131w, 1064m, 1033m, 978w, 932w, 896w, 846w.…”

“…R f (hexane/AcOEt 3 : 1) 0. See a. IC 50 Values were determined at 378 in 0.08m citric acid/Na 2 HPO 4 buffer (pH 4.2). 1 H-NMR (300 MHz, CDCl 3 ): 5.33 (t, J 9.7, HÀC(5)); 5.15 (d, J 9.7, HÀC(4)); 5.13 (dd, J 10.6, 9.3, HÀC(6)); 4.07 (dd, J 11.5, 5.6, CHÀC(7)); 3.90 (dd, J 11.5, 3.1, CH'ÀC(7)); 2.40 ± 2.29 (m, HÀC (7) (7)); 3.64, (dd, J 11.5, 5.9, CH'ÀC (7)); 3.62 (d, J 9.3, HÀC(4)); 3.43 (t, J 9.0, irrad.…”

“…Inhibition of the b-Glucosidases from Sweet Almonds, the b-Glucosidase from Caldocellum saccharolyticum and the a-Glucosidase from Brewer×s Yeast ([IC50 ] in mm at pH 6.8) by the Diaziridines 6 and 9, the Diazirine 7, the Aziridines 21 and 25, Epivalidamine (32),…”