ChemInform Abstract: Novel Synthetic Oleanane Triterpenoids: A Series of Highly Active Inhibitors of Nitric Oxide Production in Mouse Macrophages.

Abstract

The previously reported inhibitor of nitric oxide production CDDO is further modified to form derivative (VI) which is found to be an alternative agent to CDDO. -(HONDA, TADASHI; ROUNDS, BARBIEANN V.; BORE, LOTHAR; FAVALORO JR., FRANK G.; GRIBBLE, GORDON W.; SUH, NANJOO; WANG, YONGPING; SPORN, MICHAEL B.; Bioorg. Med. Chem. Lett. 9 (1999) 24, 3429-3434; Dep. Chem., Dartmouth Coll., Hanover, NH 03755, USA; EN)