ChemInform Abstract: Novel Synthesis of Pyridine‐2(1H)‐thiones, N‐Amino‐2‐pyridones, and Pyridazine Derivatives.

Elgemeie, Galal H.; El-Ezbawy, S. R.; Ramiz, M. M. M.; Mansour, O.

doi:10.1002/chin.199208225

Cited by 1 publication

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“…[ 3 ] Also, they are applicable within the industrial field in the production of dyes [ 4,5 ] and herbicides. [ 6 ] Moreover, a lot of heterocyclic ring systems were prepared through cyanoacetic acid hydrazide like pyrazoles, [ 7,8 ] thiophenes, [ 9–11 ] thiazoles, [ 12,13 ] pyrazolopyrimidines, [ 14 ] pyrimidines, [ 15,16 ] pyridines, [ 17–20 ] and others. [ 21–23 ]…”

Section: Introductionmentioning

confidence: 99%

Synthesis, reactions, and antimicrobial activity of 2‐cyano‐N′‐(4‐(2‐oxo‐2‐phenylethoxy)benzylidene)acetohydrazide derivatives

Metwally

Abdelrazek

Eldaly

2020

Journal of Heterocyclic Chem

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Knӧvenagel condensation of the starting 2-cyano-N 0-(4-(2-oxo-2-phenylethoxy)benzylidene)acetohydrazide with different aromatic aldehydes produced the comparable arylidenes derivatives. Else way, 2-cyano-N 0-(4-(2-oxo-2-phenylethoxy)benzylidene)-acetohydrazide condensed with o-hydroxybenzaldehydes affording the respective chromenes which latter underwent acid hydrolysis giving the oxo-chromenes analogues. Moreover, the reaction of 2-cyano-N 0-(4-(2-oxo-2phenylethoxy)benzylidene)acetohydrazide with istain yielded the respective indeno [2,1-b]furan derivative that was converted to its oxo-analogue through acid hydrolysis. The treatment of 2-cyano-N 0-(4-(2-oxo-2-phenylethoxy)benzylidene) acetohydrazide with α-halocompounds produced the relevant thiazoles. The enamine 2-cyano-3-(dimethylamino)-N 0-(4-(2-oxo-2-phenylethoxy)benzylidene) acrylohydrazide underwent nucleophilic substitution reaction with guanidine hydrochloride followed by heterocyclization to get the relative aminopyrimidine. Contrarily, the reaction with various 4-arylazo-3,5-diaminopyrazoles provided the relative pyrazolo[1,5-a]pyrimidines. The antimicrobial investigation was carried out for some of the newly synthesized compounds using agar well diffusion method.

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