ChemInform Abstract: Novel Synthesis of 2,6‐Benzothiazonine Derivatives.

Kim, S. H.; Kim, K.

doi:10.1002/chin.199602194

Cited by 1 publication

(1 citation statement)

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“…To identify more efficient and greener chloromethylation protocol for lignin, two conditions of Blanc reaction implied to organosolv aspen lignin were studied, both shown to be applicable for small aromatic molecules 27,28 and for aromatic macrocycles, calix [4]arenes. 15,29,30 . Our study demonstrates that the route with dichloromethyl ether and TiCl4 as Lewis acid catalyst in chloroform can hardly be applicable for lignin, yielding only 1.5% (m/m) of organic chlorine in the final product, see Table S1.…”

Section: Resultsmentioning

confidence: 99%

Chloromethylation of Lignin as a Route to Functional Material with Catalytic Properties in Cross-Coupling and Click Reactions

Mohan,

Silenko,

Krasnou

et al. 2023

Preprint

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We present a novel, greener chloromethylation procedure for organosolv aspen lignin under mild reaction conditions without Lewis acid as a catalyst and in acetic acid as a solvent. This synthetic protocol provides a reliable approach to chloromethylated lignin (CML) and means to obtain valuable lignin derivatives The resulted CML was subsequently transformed into 1-methylimidazolium lignin (ImL), which effectively serves as a stabilizing agent for Pd/CuO nanoparticles (Pd/CuO-NPs). To evaluate the versatility of developed lignin-based catalyst, we investigate its performance in a series of carbon-carbon bond formation reactions, including Suzuki-Miyaura, Sonogashira, Heck reactions, and azide-alkyne cycloaddition (click) reaction. Remarkably, this catalyst exhibited a high degree of catalytic efficiency, resulting in reactions with yields ranging from average to excellent. The heterogeneous catalyst demonstrated outstanding recyclability, enabling its reuse for at least 10 consecutive reaction cycles, with yields consistently falling within the range of 42% to 84%. A continuous flow reactor cartridge prototype employing Lignin@Pd/CuO-NPs was developed, yielding results comparable to those achieved in batch reactions. The utilization of Lignin@Pd/CuO-NPs as a catalyst showcases its potential to facilitate diverse carbon-carbon bond formation reactions and underscores its promising recyclability, aligning with the green chemistry metrics and principles of sustainability in chemical processes

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