ChemInform Abstract: Novel and Efficient Synthesis of Pyrimidine Derivatives.

Abstract

Novel and Efficient Synthesis of Pyrimidine Derivatives. -A novel two-step approach to pyrimidines (IV) via the easily accessible formamidine precursor (I) is presented. -(GHAGARE, M. G.; BIRARI, D. R.; SHELAR, D. P.; TOCHE, R. B.; JACHAK*, M. N.; Synth. Commun. 40 (2010) 11, 1580-1587,

Synthesis of Pyridin-2(1H)-one Derivatives via Enamine Cyclization

“…3-Dimethylamino-2-formyl acrylonitrile 1 was first prepared by Trofimenko from 3-amino-2-cyanoacrolein and dimethyl amine, whereas Reichardt and Kermer demonstrated the synthesis of enaminone 1 via Vilsmeier–Haack formylation of acetonitrile. In 1993 we reported a new route toward the synthesis of 1 wherein cyanoacetaldehyde was treated with dimethylformamide-dimethylacetal to offer 1 in good to moderate yield (Figure ) …”

“…Unless otherwise stated, materials were obtained from commercial suppliers and were used without further purification. Starting material 3-dimethylamino-2-formyl acrylonitrile was prepared as per our previously reported procedure . All the reactions were carried out under nitrogen atmosphere in oven-dried flasks.…”

Regioselective Synthesis of Some New Pyrazolo[1,5-a]pyrimidines, Pyrazolo[1,5-a]quinazoline and Pyrimido[4′,5′:3,4]pyrazolo[1,5-a] pyrimidines Containing Thiazole Moiety

“…Some derivatives have been studied as analogs for purine nucleoside antimetabolites . Others display antitrypanosomal or antischistosomal activities , and some derivatives show potential activity against respiratory diseases . Literature survey reveals that there are several methods for the synthesis of pyrazolo[1,5‐ a ]pyrimidines.…”