ChemInform Abstract: Nickel‐Catalyzed Borylation of Aryl‐ and Benzyltrimethylammonium Salts via C—N Bond Cleavage.

Abstract

Nickel-Catalyzed Borylation of Aryl-and Benzyltrimethylammonium Salts via C-N BondCleavage. -The catalytic system is capable of activating aryl and benzyl ammonium bonds for C-N borylation to produce a variety of organoborates. The key to the C-N bond cleavage depends on the appropriate choice of the nickel catalyst, the imidazole-based ligand, as well as the use of ethoxyethanol as the co-solvent. The transformation shows good functional group compatibility, is amenable to gram-scale synthesis and provides a tool for late-stage C-N borylation of complex compounds. -(HU, J.; SUN, H.; CAI, W.; PU, X.; ZHANG, Y.; SHI*, Z.; J. Org. Chem. 81 (2016) 1, 14-24, http://dx.