ChemInform Abstract: New Thiadiazabicyclic Compounds with Immunoregulatory Actions on Human T Lymphocytes: Comparison with Tetramisole.

Abstract

The title compounds, represented in the scheme by (IV), (V), (VII) and (IX), are prepared from (I) by similar procedures.

New Heterofused Thiazolo/Pyrazinedione Hybrids as Promising Building Blocks for Anticancer Drug Development: Synthesis, Biological and Drug‐Likeness Evaluation

“…However, in some cases, promising heterocyclic compounds such as Levamisole®, an imidazo[2,1-b] [1,3]thiazole drug with potent antihelminthic and immunomodulatory effects, [1] have shown serious adverse effects. [2] Such adverse effects and the potential development of drug-resistance make it necessary to join efforts to access better and more selective chemotherapeutic agents. In the search for novel bioactive compounds, molecular hybridization has recently emerged as a potent synthetic strategy.…”

“…Several studies that involve heterocycle synthesis have led to powerful therapeutic agents. However, in some cases, promising heterocyclic compounds such as Levamisole®, an imidazo[2,1‐ b ][1,3]thiazole drug with potent antihelminthic and immunomodulatory effects, [1] have shown serious adverse effects [2] . Such adverse effects and the potential development of drug‐resistance make it necessary to join efforts to access better and more selective chemotherapeutic agents.…”