ChemInform Abstract: New Synthetic Methodology Toward Macrolides/Macrolactams via Palladium‐Catalyzed Carbon—Heteroatom Bond‐Forming Reactions.

Abstract

New Synthetic Methodology Toward Macrolides/Macrolactams via Palladium--Catalyzed Carbon-Heteroatom Bond-Forming Reactions. -The process allows an access to 11-to 16-membered ring systems and only easily removable alcohols and CO2 are formed as by-products. In most cases, lower amounts of exocyclic alkenes such as (IV) are also observed. -(SENGOKU, T.; HAMAMATSU, T.; INUZUKA, T.; TAKAHASHI, M.; YODA*, H.; Synlett 2011, 12, 1766-1768, http://dx.doi.org/10.1055/s-0030-1260812 ; Dep. Mater. Sci., Fac. Eng., Shizuoka Univ., Hamamatsu, Shizuoka 432, Japan; Eng.) -Mais 50-160