ChemInform Abstract: New Synthesis of Simvastatin.

Abstract

Other bioactive products U 1300New Synthesis of Simvastatin. -Key step in the new synthesis of simvastatin (V), an analogue of the fermentation product lovastatin (I), is the opening of the lactone ring after protection of the hydroxyl group. -(SINGAMSETTY, R. K.; VUJJINI, S. K.; MANNE, N.; NAGA, B. R. M. V.; HIMABINDU, V.; BATTACHARYA, A.; GHANTA, M. R.; BANDICHHOR*, R.; Synth. Commun. 38 (2008) 24, 4452-4459; Innovation Plaza, Res. Dev., Dr. Reddy's Lab. Ltd., Qutubullapur, R. R. Dist. 502 625, India; Eng.) -M. Bohle 18-206