ChemInform Abstract: Molecular Rearrangements of 4‐Iminomethyl‐1,2,3‐Triazoles. Replacement of 1‐Aryl Substituents in 1H‐1,2,3‐Triazole‐4‐carbaldehydes.

Abstract

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2H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design

“…Buchwald-type aminations led, as reported, exclusively to N 2 -substituted triazoles . The N 1 -, N 2 -, or N 3 -substitution pattern of N -substituted 1,2,3-triazole-4- or 5-carboxylates was determined based on (i) existing reports, − (ii) the lower polarity of the N 2 -substituted triazoles in comparison to their corresponding regioisomers, and (iii) 1 H and 13 C NMR as well 15 N-HMBC and NOESY experiments (see Section S4 in the SI for a more detailed analysis). The 2 H -substituted triazolyl ethyl esters 19c – q were subsequently saponified with LiOH in 2:2:1 H 2 O/THF/MeOH, giving carboxylic acids 21c – q .…”

Solvent Coligand-Induced Spin State Variation in Iron(II) Complexes Bearing Pentadentate N5 Ligand Toward the Construction of an N5O Spin Crossover Center

“…For 1 , the linear pentadentate ligand L 3‑Me‑3 Me was prepared by mixing 3,3′-diamino- N -methyldipropylamine and 1-methyl-1 H -1,2,3-triazole-4-carbaldehyde , with 1:2 molar ratio in MeCN. The iron­(II) complex 1 was prepared by mixing the ligand solution in MeCN, methanolic solutions of FeCl 2 ·4H 2 O, and NaBPh 4 with a 1:1:2 molar ratio under an inert nitrogen atmosphere at ambient temperature.…”

“…All reagents and solvents were purchased from commercial sources and used for the syntheses without further purification. The 1-methyl-1 H -1,2,3-triazole-4-carbaldehyde was prepared by following the literature procedure. , Complexation and crystallization of iron­(II) complexes were performed under a nitrogen atmosphere using standard Schlenk techniques. Other synthetic procedures were carried out in air.…”