ChemInform Abstract: Microwave‐Assisted Ring‐Opening of Epoxides with N‐Biaryl Sulfonamides in the Synthesis of Matrix Metalloproteinase‐9 Inhibitors.

Abstract

9 Inhibitors. -The process is investigated for a broad spectrum of substrates. Some products, for example (R)-(VII), are transformed to hydroxamates [cf. (X)] which exhibit good to excellent activity. -(YANG*, S.-M.; MURRAY, W. V.; Tetrahedron Lett. 49 (2008) 5, 835-839; Johnson & Johnson Pharm. Res. Dev., Cranbury, NJ 08512, USA; Eng.) -Mais 20-065