ChemInform Abstract: Microwave Assisted Novel Synthesis of Isoxazole and Their Antibacterial Activity.

Abstract

Novel isoxazolylchromenones (V) are synthesized via Baker—Venkataraman transformation of esters (III) and subsequent microwave‐assisted reaction of the obtained propanediones (IV) with hydroxylamine.

An Efficient Method for the Synthesis of Isoxazolines Under Microwave Irradiation and Solvent-Free Conditions

“…From the literature survey, it was found that large numbers of isoxazoline derivatives of pharmacological significance were synthesized by the action of hydroxylamine hydrochloride on chalcones in presence of base [14][15][16][17][18][19] . In present communication we have synthesized isoxazolines from chalcones and hydroxylamine hydrochloride using basic alumina as solid support under microwave and the structures of the compounds were confirmed by 1 H NMR, IR, mass spectra and elemental (C, H, N) analysis.…”

A One-Pot Approach to Δ2-Isoxazolines from Ketones and Arylacetylenes

“…Commonly, isoxazoline derivatives are constructed by 1,3-dipolar cycloaddition of alkenes to nitrile oxides generated in situ by dehydration of nitro compounds or dehydrogenation of oximes. ,,, 3-Acetyl- and 3-benzoyl isoxazolines were synthesized by the reaction of alkenes with acetone or acetophenone in the presence of (NH 4 ) 2 Ce(NO 3 ) 6 or (NH 4 ) 2 Ce(NO 3 ) 5 ·4H 2 O involving the intermediate nitro ketones which were further oxidized to the nitrile oxides. Δ 2 - Isoxazolines are also formed via base-catalyzed or catalyst-free cyclization of α,β-unsaturated ketones with hydroxylamine. ,, Isoxazolinylacetates were synthesized from oximes of β,γ-unsaturated ketones by their palladium-mediated nucleometalation/methoxycarbonylation . The same oximes when subjected to palladium-catalyzed [Pd(dba) 3 /phosphine/NaOBu t ] carboetherification together with arylbromides gave 3-aryl-5-benzyl Δ 2 - isoxazolines …”