ChemInform Abstract: Microbial Transformation of 1,9‐Dideoxyforskolin to Forskolin (I).

Abstract

(NADKAR‐ NI, S.R.; AKUT, P.M.; GANGULI, B.N.; KHANDELWAL, YL; DE SOUZA, N.J.; RUPP, R.H.; FEHLHABER, H.W.; Tetrahedron Lett.

Identification of Microbial Transformation Products of 1, 9-Dideoxyforskolin and 7-Deacetyl-1, 9-dideoxyforskolin

“…It has promising biological and chemical potential (1). We have recently described the utilisation of inactive forskolin-related plant metabolites such as 1 ,9-dideoxyforskolin (2) for conversion to the bioactive forskolin molecule, through microbial transformation of its 7-deacetyl derivative to 7deacetylforskolin (2). The finding of a useful Scopuloriopsis strain, as one of 236 tested fungal isolates, came about in a programme especially designed for the purpose of effecting the desired transformation.…”

“…This strategy of monitoring the transformation products by determining a triad of retention times from the three chromatographic assays permitted a rapid assessment of the capability of fungal strains not only to hydroxylate a 1,9-dideoxyforskolin derivative to a forskolin derivative, but also to effect other transformations leading to the novel forskolin metabolites described in our earlier publications (2,4). Materials and Methods (5,6,8) Standard samples…”