The article mainly argues with the latest progress of methodologies which is the introduction of a difluoromethylene unit into the organic compounds. It will also summarize the theoretical study of introducing gem-difluoromethylene group into the organic molecular. Firstly, it briefly reviews the function of difluoromethylation reaction; secondly, we start to study the recent development of introducing a CF2group in the organic synthesis. At last but not the least, we conclude the use of the new CF2unit in the syntheis of the molecular.