ChemInform Abstract: Liquid‐Crystalline Imidazo(2,1‐b)‐1,3,4‐thiadiazoles. Part 1. Synthesis, Mesomorphic and Spectral Characteristics of 2,6‐Disubstituted Imidazo(2,1‐b)‐1,3,4‐thiadiazoles.

Abstract

The novel title compounds (V) form smectic mesophases over a wide range of temperature.

Identification of a Selective Inverse Agonist for the Orphan Nuclear Receptor Estrogen-Related Receptor α

“…Thiadiazoloacrylamide analogues reported in this work were prepared by the synthetic route shown in Scheme . The 2-alkyl-5-amino[1,3,4]thiadiazole derivatives 5 were commercially available or readily prepared from acid chlorides and thiosemicarbazide, via cyclodehydration of the acylthiosemicarbazide intermediate under acidic conditions . The thiadiazoloacetamides 4 were prepared from the amino thiadiazoles 5 and ethyl cyanoacetate in a refluxing MeONa/MeOH mixture.…”

Synthesis and Antibacterial Activities of Novel Imidazo[2,1-b]-1,3,4-thiadiazoles

“…2-Amino-1,3,4-thiadiazole derivatives are well known as compounds of a wide range of anticancer activity [ 1 , 2 , 3 , 4 ] that have been prepared from their respective aldehydes [ 5 ] or carboxylic acids [ 6 ]. They appeared to be the most feasible route to fused imidazo[2,1- b ]-1,3,4-thiadiazole rings [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ] of interesting potential applications [ 15 , 16 ]. Some of these compounds show anticancer [ 17 ], antitubercular [ 18 ], antibacterial [ 19 ], antifungal [ 20 ], anticonvulsant analgesic [ 21 ], antisercetory [ 22 ] and antiapoptotic [ 23 ] properties.…”