ChemInform Abstract: Lanostane‐Type Triterpenes from the Fungal Endophyte Scleroderma UFSMSc1 (Persoon) Fries.

Morandini, Liziane Maria Barassuol; Neto, Alexandre T.; Pedroso, Marcelo; Antoniolli, Zaida Inês; Burrow, Robert A.; Bortoluzzi, Adaílton J.; Mostardeiro, Marco A.; Silva, Ubiratan F. da; Dalcol, Ionara I.; Morel, Ademir F.

doi:10.1002/chin.201626211

Cited by 2 publications

(3 citation statements)

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“…These results confirmed the anti‐dengue potential of triterpenoids endowed with a lupane‐type skeleton, as exemplified by betulinic acid 3 β ‐caffeate, which significantly inhibited RdRp activity . More generally, antiviral properties of betulinic acid ( 4 ), betulin ( 5 ) and betulinic aldehyde ( 6 ), the three most common molecules of this chemical series, have been often reported against various types of viruses …”

Section: Resultssupporting

confidence: 76%

“…Previous studies have shown that endophytes were able to produce triterpenoids. For example, lanostane‐type triterpenoids were isolated from the endophytes Scleroderma sp., Ceriporia lacerate , and Diaporthe sp . Oleane‐type triterpenoids were isolated from Xylaria papulis , Pestalotiopsis clavispora , and ursane‐type triterpenoids were isolated from Annulohypoxylon stygium and Pestalotiopsis clavispora .…”

Section: Resultsmentioning

confidence: 99%

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Betulinic Acid, The First Lupane‐Type Triterpenoid Isolated from Both a Phomopsis sp. and Its Host Plant Diospyros carbonaria Benoist

Peyrat

Éparvier

Eydoux

et al. 2016

Chemistry & Biodiversity

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Following a biological screening using a dengue replicon virus-cell-based assay, Diospyros carbonaria AcOEt extract was investigated, affording six known lupane-type triterpenoids endowed with anti-DENV-2 NS5 polymerase activity. The study of the associated microbial community of this species permitted us to identify 38 endophytes belonging to five different orders. Nine out of these 38 strains showed significant activity on the dengue replicon assay. The chemical investigation of the most active one, Phomopsis sp. SNB-LAP1-7-32, led to the isolation of betulinic acid, an anti-viral secondary metabolite isolated previously from the host plant. This result is the first example of a lupane-type triterpenoid isolated from both an endophyte and its host plant. Its presence in the Phomopsis strain may result from gene transfer and/or specific niche selection.

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Section: Resultssupporting

confidence: 76%

Section: Resultsmentioning

confidence: 99%

Betulinic Acid, The First Lupane‐Type Triterpenoid Isolated from Both a Phomopsis sp. and Its Host Plant Diospyros carbonaria Benoist

Peyrat

Éparvier

Eydoux

et al. 2016

Chemistry & Biodiversity

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“…A group of triterpene and steroids were also found including epidihydrocholesterin, androstenediol, and methandriol. Several reports of related structures for these compounds also support our findings as hit candidates [60][61][62][63][64][65]. Two tropane derivatives were also found, they are structurally related to benzotropine which has been reported as active [57].…”

Section: Ligand-based Virtual Screeningsupporting

confidence: 88%

Similarity searching for anticandidal agents employing a repurposing approach

Rodríguez‐Villar,

Cortés‐Benítez,

Palacios‐Espinosa

et al. 2024

Molecular Informatics

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Fungal infections caused by Candida are still a public health concern. Particularly, the resistance to traditional chemotherapeutic agents is a major issue that requires efforts to develop new therapies. One of the most interesting approaches to finding new active compounds is drug repurposing aided by computational methods. In this work, two databases containing anticandidal agents and drugs were studied employing cheminformatics and compared by similarity methods. The results showed 36 drugs with high similarities to some candicidals. From these drugs, trimetozin, osalmid and metochalcone were evaluated against C. albicans (18804), C. glabrata (90030), and miconazole‐resistant strain C. glabrata (32554). Osalmid and metochalcone were the best, with activity in the micromolar range. These findings represent an opportunity to continue with the research on the potential antifungal application of osalmid and metochalcone as well as the design of structurally related derivatives.

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ChemInform Abstract: Lanostane‐Type Triterpenes from the Fungal Endophyte Scleroderma UFSMSc1 (Persoon) Fries.

Cited by 2 publications

References 1 publication

Betulinic Acid, The First Lupane‐Type Triterpenoid Isolated from Both a Phomopsis sp. and Its Host Plant Diospyros carbonaria Benoist

Betulinic Acid, The First Lupane‐Type Triterpenoid Isolated from Both a Phomopsis sp. and Its Host Plant Diospyros carbonaria Benoist

Similarity searching for anticandidal agents employing a repurposing approach

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