ChemInform Abstract: L‐Selectride‐Mediated Highly Diastereoselective Asymmetric Reductive Aldol Reaction: Access to an Important Subunit for Bioactive Molecules.
Abstract:Alcohols P 0110 L-Selectride-Mediated Highly Diastereoselective Asymmetric Reductive Aldol Reaction: Access to an Important Subunit for Bioactive Molecules. -The reaction of the enolates of chiral and achiral enones, generated in situ via L-Selectride reduction, with chiral α-alkoxyaldehydes affords α,α-dimethyl-β-hydroxyketones as synthons of natural products. -(GHOSH*, A. K.; KASS, J.; ANDERSON, D. D.; XU, X.; MARIAN, C.; Org. Lett. 10 (2008) 21, 4811-4814; Dep. Chem., Purdue Univ., West Lafayette, IN 47907,… Show more
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