ChemInform Abstract: Ipso and cine Substitution of Bromine in Pyridazinones.

Abstract

Ipso and cine Substitution of Bromine in Pyridazinones.-The X-ray structures of compounds (III), (VI), (VIII), and (IX) are given. -(KATRUSIAK, A. A.; KATRUSIAK, A.; BALONIAK, S.; ZIELINSKA, K.; Pol.

Study on the 4-ethoxy-2-methyl-5-(4-morpholinyl)-3(2H)-pyridazinone using FT-IR,1H and13C NMR, UV-vis spectroscopy, and DFT/HSEH1PBE method

“…1. Furthermore, the selected some optimized molecular geometry parameters of the title molecule are given in Table 1 which also includes the experimental values obtained for the 6-methoxy-5-morpholino-2-phenyl-3-pyridazinone as the most closely related structure in the literature in order to compare to our calculated results [30]. On the other hand, as seen in Table 1 Furthermore, by considering some selected dihedral angles of the title compound exhibited in Table 1.We should express that the compound under investigation is a non-planar molecule.…”

Facile Synthesis of New [1,2,4]Triazolo[4,3‐b]pyridazine

“…In the last decades, the chemistry of triazolo [4,3-b] pyridazine derivatives has received considerable attention owing to their varied biological activities, such as antiviral [1], antitumor [2,3], sedative/hypnotic [4], anti-anxiety [5][6][7], adenine receptor ligand [8,9], hypotensive [10], herbicidal, pesticidal [11], bactericidal [12] and anti-HAV activity [13]. In the light of these information and due to our continuing interest in the synthesis of biologically important heterocycles [14][15][16] in this paper, we wish to report the facile syntheses of some new derivatives of triazolo [4,3-b]pyridazines.…”

Anti‐HAV Activity of Some Newly Synthesized Triazolo[4,3‐b]pyridazines

“…In the last few decades, the chemistry of triazolo [4,3-b]pyridazine derivatives has received considerable attention owing to their variety of biological activities, especially as a potential antiviral [1], antitumoral [2,3], sedative/hypnotic [4], anti-anxiety [5 -7], adenine receptor ligand [8,9], hypotensive and heart rate activity [10], as herbicidal, pesticidal [11], and bactericidal [12]. In connection with our research program for the synthesis of different fused heterocyclic compounds with antiviral [1,13,14] and antimicrobial interest [15 -19], we describe the syntheses of some triazolo [4,3-b]pyridazine derivatives with promising anti-HAV activity.…”