ChemInform Abstract: Inversion of the Stereoselectivity in the Reduction of the Carbonyl Group in a Precursor to Forskolin (IV) by the NaBH4/CeCl3 Reagent.

Abstract

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Novel preparation of substituted oxazolines condensed to d-ring of estrane skeleton and characterization of their antiproliferative properties

“…Only a few examples can be found in the literature that use this method for the reduction of saturated ketone to promote the formation of an equatorial over an axial alcohol. This effect is most important in the case of sterically crowded ketones [18]. In 2010, a series of keto steroids were reduced with NaBH 4 in the presence of lanthanoid chlorides in MeOH by Chodounská et al [19].…”