ChemInform Abstract: Indolizines and Pyrrolo[1,2‐c]pyrimidines Decorated with a Pyrimidine and a Pyridine Unit Respectively.

Abstract

Indolizines and Pyrrolo[1,2-c]pyrimidines Decorated with a Pyrimidine and a Pyridine UnitRespectively. -4-(4-Pyridyl)pyrimidine (I) and its 3-pyridyl-isomer (V) undergo quaternization reactions at the pyridine ring in reactions with bromoacetophenones, whilst the 4-(2-pyridyl)pyrimidine (VIII) suffers quaternization at the pyrimidine ring due to steric hindrance. 1,3-Dipolar cycloaddition of the N-ylides thus obtained with alkynes (II) provides access to new indolizines or pyrrolopyrimidines, respectively. -(POPA*, M. M.; GEORGESCU, E.; CAIRA, M. R.; GEORGESCU, F.; DRAGHICI, C.; STAN, R.; DELEANU, C.; DUMITRASCU, F.; Beilstein J. Org. Chem. 11 (2015) 1079-1088, http://dx.doi.org/10.3762/bjoc.11.121 ; Nenitzescu Cent. Org. Chem., Roum. Acad., RO-060023 Bucharest, Rom.; Eng.) -C. Cyrus