ChemInform Abstract: InCl₃‐Catalyzed Synthesis of 2‐Aryl Quinazolin‐4(3H)‐ones and 5‐Aryl Pyrazolo[4,3‐d]pyrimidin‐7(6H)‐ones and Their Evaluation as Potential Anticancer Agents.

Abstract

A novel approach to title compounds, e.g. (III) and (VI), is reported.

Discovery of natural alkaloid bouchardatine as a novel inhibitor of adipogenesis/lipogenesis in 3T3-L1 adipocytes

“…1), a b-indoloquinazoline alkaloid isolated from B. neurococca (Rutaecae), exhibits a variety of biological effects, such as anti-cancer, anti-inflammatory, and anti-tuberculosis effects. 21,22 In the present study, we evaluated, http for the first time, the inhibitory effects of 1, which was synthesized using a method in the literature (Scheme 1) on adipogenesis and lipogenesis in 3T3-L1 cell. In addition, we investigated the molecular mechanisms of 1 by analyzing the expression of adipogenic factors at mRNA and protein levels.…”

Synthesis of 8-Trifluloromethyl-2-Thioquinazolin-(3H)-4-One Nucleosides

“…E., et al, 2013;Kumar A. et al, 2011;Amin K.M. et al, 2010;Aly M.M., 2010;Al-Rashood S.T., 2006 andMulakayala N., 2012).…”

UV-Light-Induced Dehydrogenative N-Acylation of Amines with 2-Nitrobenzaldehydes To Give 2-Aminobenzamides

“…2-Aminobenzamides and their derivatives, which are generally used for the preparation of complex nitrogencontaining compounds (see Figure 1A), [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] have attracted special research interest due to their remarkable applications as important reactive intermediates in organic synthesis, such as in the synthesis of the quinazoline derivatives 19 Hyminal (methaqualone), Afloqualone, Luotonin F, Bouchardatine, Sildenafil, etc. (see Figure 1B).…”

“…[1][2][3][4][5][6][7][8][9][10][11] These skeletons could be easily synthesized from 2-aminobenzamides. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Besides, these 2-aminobenzamides scaffolds also exist in various biological active agents such as anticancer, antimicrobial, anti-inflammatory, anticonvulsant, anti-tubercular, antiviral, and antimalarial agents. 1,6,9,11 Therefore, the synthesis of 2-aminobenzamides plays an important role in organic synthesis.…”

“…(see Figure 1B). [1][2][3][4][5][6][7][8][9][10][11] These skeletons could be easily synthesized from 2-aminobenzamides. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Besides, these 2-aminobenzamides scaffolds also exist in various biological active agents such as anticancer, antimicrobial, anti-inflammatory, anticonvulsant, anti-tubercular, antiviral, and antimalarial agents.…”