ChemInform Abstract: HLA and Cancer: 12<sup>th</sup> International Histocompatibility Workshop Study

Garrido, Federico; Cabrera, Teresa; Accolla, Rs; Bensa, Jean‐Claude; Bodmer, W F; Dohr, Gottfried; Drouet, M; Fauchet, R.; Ferrara, G.B.; Ferrone, Soldano; Giacomini, Patrizio; Kageshita, Toshiro; Koopman, Louise A.; Maio, Michele; Marincola, Franco; Mazzilli, Cristina; Morel, P; Murray, Andrea; Papasteriades, Crh; Salvaneschi, L.; Stern, P; Ziegler, Andreas

doi:10.1002/chin.200027291

Cited by 15 publications

(17 citation statements)

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“…A loss or down-regulation of HLA class I antigens in tumor cells has been frequently observed in a variety of human malignancies, and this represents an important cancer-immune escape mechanism [130][131][132][133][134]. Using a panel of monoclonal antibodies on tumor tissue sections, these loss or down-regulation has been found in 60-90% of tumors [135][136][137][138][139][140].…”

Section: Combination With a Checkpoint Inhibitor: Expansion Of The Thmentioning

confidence: 99%

Clinical Applications of Natural Killer Cells

Harada¹,

Teraishi²,

Ishii³

et al. 2017

Natural Killer Cells

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Natural killer (NK) cells are an essential component of the innate immune system, and they play a crucial role in immunity against malignancies. Recent advances in our understanding of NK cell biology have paved the way for new therapeutic strategies based on NK cells for the treatment of various cancers. In this section, we will focus on NK cell immunotherapy, including the enhancement of antibody-dependent cellular cytotoxicity, the manipulation of receptor-mediated activation, inclusion criteria based on killer cell immunoglobulin-like receptor (KIR) ligand mismatches, and adoptive immunotherapy with ex vivo expanded chimeric antigen receptor (CAR)-engineered or engager-modified NK cells. In contrast to T lymphocytes, donor NK cells do not attack any recipient tissues based on allogeneic human leukocyte antigens (HLAs), suggesting that NK-mediated antitumor effects may be achieved without the risk of graft-versus-host disease (GvHD). Despite reports of clinical efficacy, the application of NK cell immunotherapy is limited. Developing strategies for manipulating NK cell products, host factors, and tumor targets are thus current subjects of diligent study. Research into the biology of NK cells has indicated that NK cell immunotherapy has the potential to become the forefront of cancer immunotherapy in the coming years.

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Section: Combination With a Checkpoint Inhibitor: Expansion Of The Thmentioning

confidence: 99%

Clinical Applications of Natural Killer Cells

Harada¹,

Teraishi²,

Ishii³

et al. 2017

Natural Killer Cells

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“…Normal lymphocytes and vessel endothelia were used in each specimen as internal controls. Tumor specimens were scored as positive, heterogeneous, or negative when the percentage of stained tumor cells in an entire lesion was 75%, 25% to 75%, and B25%, respectively, according to the criteria established by the HLA and cancer component of the 12th International Histocompatibility Workshop [26]. Scoring for presence of T cells was categorized based on the number of T cells per high-power field (40)): 0 (0 T cells), 1'(55 T cells), 2' (6Á19 T cells), or 3' (]20 T cells) ( Figure 2B) [27].…”

Section: Immunohistochemistrymentioning

confidence: 99%

Down-regulation of HLA class I antigen-processing machinery components in esophageal squamous cell carcinomas: Association with disease progression

Liu

Hao

et al. 2009

Scandinavian Journal of Gastroenterology

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“…Immunoreactivity with the different mAbs was graded in accordance with the recommendations of the 12th IHW (15) as negative (<25% cells stained), heterogeneous (25–75% cells stained), or positive (>75% cells stained).…”

Section: Methodsmentioning

confidence: 99%

Higher HLA class I expression in renal cell carcinoma than in autologous normal tissue

et al. 2010

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A total of 93 frozen primary renal cell carcinoma (RCC) samples and 31 frozen samples of corresponding normal renal tissue were analyzed for human leukocyte antigen (HLA) class I and HLA-DR expression. Unexpectedly, HLA class I expression was much higher on RCC cells than on normal renal tubular cells. Immunohistochemistry analysis of frozen and paraffin-embedded tissue samples, applying an extended panel of specific anti-HLA monoclonal antibodies, showed elevated HLA class I antigen expression in 95.6% of the tumors vs only 12.9% of normal renal tissues. These findings were confirmed by molecular analysis of HLA heavy chain and beta2-microglobulin (beta2m) transcription levels using quantitative real-time polymerase chain reaction (PCR) on microdissected tissue samples (isolated tumor nests and autologous normal renal tubules) from four patients. These results might help to explain the relatively high success rate of immunotherapy in patients with RCC. The molecular mechanism underlying the increased HLA class I expression in RCC has yet to be elucidated.

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ChemInform Abstract: HLA and Cancer: 12^th International Histocompatibility Workshop Study

Cited by 15 publications

References 0 publications

Clinical Applications of Natural Killer Cells

Clinical Applications of Natural Killer Cells

Down-regulation of HLA class I antigen-processing machinery components in esophageal squamous cell carcinomas: Association with disease progression

Higher HLA class I expression in renal cell carcinoma than in autologous normal tissue

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ChemInform Abstract: HLA and Cancer: 12th International Histocompatibility Workshop Study

Cited by 15 publications

References 0 publications

Clinical Applications of Natural Killer Cells

Clinical Applications of Natural Killer Cells

Down-regulation of HLA class I antigen-processing machinery components in esophageal squamous cell carcinomas: Association with disease progression

Higher HLA class I expression in renal cell carcinoma than in autologous normal tissue

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Resources

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ChemInform Abstract: HLA and Cancer: 12^th International Histocompatibility Workshop Study