ChemInform Abstract: Histamine Analogues: Imidazolylalkylguanidines. Synthesis and in vitro Pharmacology.

Abstract

Histamine Analogues: Imidazolylalkylguanidines.Synthesis and in vitro Pharmacology.-Title compounds like (IV) and (VII) (10 examples) show weak H1-antagonistic activity on guinea pig ileum but good H2-agonistic activity on isolated guinea pig right atrium. (IVa) and (IVb) are more potent H2-agonists than histamine.-(SELLIER, C.; ELZ, S.; BUSCHAUER, A.; SCHUNACK, W.; Eur.