ChemInform Abstract: Highly Stereoselective Synthesis of Terminal Chloro‐Substituted Propargylamines and Further Functionalization.

Abstract

The reaction of chiral N‐tert‐butylsulfinyl imines (II) and (V) with in situ generated lithium chloroacetylene affords desired terminal chloro‐substituted propargylamines (III) and (VI), resp., which are converted into terminal acetylene (IV), carboxylic acid (VIII), propargylic alcohols (X), and N‐alkylated derivatives (XII).