ChemInform Abstract: Highly Stereoselective Synthesis of Cyclopropylphosphonates Catalyzed by Chiral Ru(II)‐Pheox Complex.

Abstract

Highly Stereoselective Synthesis of Cyclopropylphosphonates Catalyzed by Chiral Ru(II)-Pheox Complex. -A highly stereoselective cyclopropanation of alkenes with diethyl diazomethylphosphonate is achieved in the presence of the Ru(II)-Pheox complex (RPH) as catalyst. Moreover, the synthesis of compound (VII) is also demonstrated which acts as key intermediate for the synthesis of a published nucleotide analogue. -(CHANTHAMATH, S.; OZAKI, S.; SHIBATOMI, K.; IWASA*, S.; Org. Lett. 16 (2014) 11, 3012-3015, http://dx.doi.org/10.1021/ol501135p ; Dep. Environ. Life Sci., Toyohashi Univ. Technol., Toyohashi, Aichi 441, Japan; Eng.) -Mais 48-054